Translating IL-6 biology into effective treatments
Identifieur interne : 000059 ( 2020/Analysis ); précédent : 000058; suivant : 000060Translating IL-6 biology into effective treatments
Auteurs : Ernest H. Choy [Royaume-Uni] ; Fabrizio De Benedetti [Italie] ; Tsutomu Takeuchi [Japon] ; Misato Hashizume [Japon] ; Markus R. John [Suisse] ; Tadamitsu Kishimoto [Japon]Source :
- Nature Reviews. Rheumatology [ 1759-4790 ] ; 2020.
Abstract
In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still’s disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and cytokine release syndrome. Targeting this pathway has also identified avenues for potential expansion into several other indications, such as uveitis, neuromyelitis optica and, most recently, COVID-19 pneumonia. To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases.
Url:
DOI: 10.1038/s41584-020-0419-z
PubMed: 32327746
PubMed Central: 7178926
Affiliations:
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PMC:7178926Le document en format XML
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Choy</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0807 5670</institution-id><institution-id institution-id-type="GRID">grid.5600.3</institution-id><institution>Division of Infection and Immunity, CREATE Centre,</institution><institution>Cardiff University,</institution></institution-wrap>Cardiff, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiff</wicri:regionArea></affiliation></author><author><name sortKey="De Benedetti, Fabrizio" sort="De Benedetti, Fabrizio" uniqKey="De Benedetti F" first="Fabrizio" last="De Benedetti">Fabrizio De Benedetti</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0727 6809</institution-id><institution-id institution-id-type="GRID">grid.414125.7</institution-id><institution>Division of Rheumatology and Laboratory of ImmunoRheumatology,</institution><institution>Ospedale Pediatrico Bambino Gesù,</institution></institution-wrap>Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Rome</wicri:regionArea></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hashizume, Misato" sort="Hashizume, Misato" uniqKey="Hashizume M" first="Misato" last="Hashizume">Misato Hashizume</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.418587.7</institution-id><institution>Chugai Pharmaceutical Co., Ltd,</institution></institution-wrap>Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="John, Markus R" sort="John, Markus R" uniqKey="John M" first="Markus R." last="John">Markus R. John</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 1269</institution-id><institution-id institution-id-type="GRID">grid.417570.0</institution-id><institution>F. Hoffmann-La Roche AG,</institution></institution-wrap>Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Basel</wicri:regionArea></affiliation></author><author><name sortKey="Kishimoto, Tadamitsu" sort="Kishimoto, Tadamitsu" uniqKey="Kishimoto T" first="Tadamitsu" last="Kishimoto">Tadamitsu Kishimoto</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0373 3971</institution-id><institution-id institution-id-type="GRID">grid.136593.b</institution-id><institution>Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center,</institution><institution>Osaka University,</institution></institution-wrap>Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Reviews. Rheumatology</title><idno type="ISSN">1759-4790</idno><idno type="eISSN">1759-4804</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still’s disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and cytokine release syndrome. Targeting this pathway has also identified avenues for potential expansion into several other indications, such as uveitis, neuromyelitis optica and, most recently, COVID-19 pneumonia. To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kishimoto, T" uniqKey="Kishimoto T">T Kishimoto</name></author><author><name sortKey="Ishizaka, K" uniqKey="Ishizaka K">K Ishizaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, T" uniqKey="Hirano T">T Hirano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashizume, M" uniqKey="Hashizume M">M Hashizume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garbers, C" uniqKey="Garbers C">C Garbers</name></author><author><name sortKey="Heink, S" uniqKey="Heink S">S Heink</name></author><author><name 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Tanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurram, M" uniqKey="Gurram M">M Gurram</name></author><author><name sortKey="Pahwa, S" uniqKey="Pahwa S">S Pahwa</name></author><author><name sortKey="Frieri, M" uniqKey="Frieri M">M Frieri</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>Suisse</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Choy, Ernest H" sort="Choy, Ernest H" uniqKey="Choy E" first="Ernest H." last="Choy">Ernest H. Choy</name></noRegion></country><country name="Italie"><noRegion><name sortKey="De Benedetti, Fabrizio" sort="De Benedetti, Fabrizio" uniqKey="De Benedetti F" first="Fabrizio" last="De Benedetti">Fabrizio De Benedetti</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name></noRegion><name sortKey="Hashizume, Misato" sort="Hashizume, Misato" uniqKey="Hashizume M" first="Misato" last="Hashizume">Misato Hashizume</name><name sortKey="Kishimoto, Tadamitsu" sort="Kishimoto, Tadamitsu" uniqKey="Kishimoto T" first="Tadamitsu" last="Kishimoto">Tadamitsu Kishimoto</name></country><country name="Suisse"><noRegion><name sortKey="John, Markus R" sort="John, Markus R" uniqKey="John M" first="Markus R." last="John">Markus R. John</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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